Lance's Corner

NIDCR Issues Latest Newsletter

Jun 5, 2024

The National Institute of Dental and Craniofacial Research (NIDCR) has issued its latest newsletter, which can be read below.

NIDCR's quarterly newsletter

In this issue:

NIDCR News Grantee News
Training News NIH/HHS News
Science Advances Subscribe to NIDCR News
 

June 5: NIH Barmes Lecture Returns with Ambassador John Nkengasong

Barmes lectureThe Fogarty International Center and NIDCR will co-host the 2024 David E. Barmes Global Health Lecture: Global HIV/AIDS Response: Then, Now, Future, by Ambassador John Nkengasong, Ph.D., U.S. Global AIDS Coordinator and Senior Bureau Official for Global Health Security and Diplomacy. The lecture will take place on Wednesday, June 5, from 1:00-2:00 p.m. ET in the Natcher Conference Center on the NIH campus and via videocast.

Resolution Honoring NIDCR’s 75th Anniversary Passed in U.S. Senate

photo of the CapitolWith unanimous support, the U.S. Senate introduced and passed a resolution recognizing NIDCR’s 75th anniversary. The resolution recognizes the institute’s role in improving the dental, oral, and craniofacial health of the nation through research, training, and the dissemination of health information.

Recording Now Available: Sealant Implementation Webinar

child smiling in dentist chairIn observance of National Children’s Dental Health Month, NIDCR and the American Dental Association jointly held a webinar featuring a panel discussion on the current landscape of dental sealant uptake and implementation for prevention of caries in children, particularly among those from underrepresented groups.

Nadine Samara Finds Her Calling at NIH

photo of people standing and smilingIn recognition of Women’s History Month, the NIH Record published a profile on NIDCR Stadtman Tenure-Track Investigator Nadine Samara, Ph.D., who studies the sugars that bacteria make and use to evade the host immune system. In the profile, she stressed the importance of making people feel safe, supported, and mentored in her lab.

Save the Date: NIH Professional Development & Networking Workshop — September 24-25

graphic of researchersThe 2024 NIH Diversity Supplement Professional Development and Networking Workshop will take place September 24-25, bringing together scholars from NIH institutes and centers, including NIDCR. The virtual event will demystify the NIH grant process and allow scholars to meet NIH program staff, present their research, and network.

NIH To Increase Pay Levels for Pre- and Postdoctoral Scholars at Grantee Institutions

photo of a scientist working in a labNIH will increase annual pay levels for research trainees who receive the Ruth L. Kirschstein National Research Service Awards at NIH-funded external institutions. The increase applies to more than 17,000 predoctoral and postdoctoral scholars and includes additional funds for childcare and training-related expenses.

Interested in Becoming an NIDCR Trainee? Apply Now

Healthy Mouth, Healthy Body

Mouse amyloid plaque imageFor the last 40 years, NIDCR has supported research on the biological links between the mouth and the rest of the body, commonly known as the “oral-systemic connection.” In that time, scientists have unveiled a multitude of connections between oral diseases such as gum disease and tooth decay, and conditions like diabetes, dementia, cardiovascular disease, preterm birth, AIDS, and cancers, among others.

Facing Cancer Head-On

Colorized scanning electron micrographWe need better ways to treat and prevent head and neck cancers, which often go undetected until they’re quite advanced. From cancer vaccines and tumor-killing therapies to computer algorithms that map suspicious growths in the mouth, ongoing NIDCR-supported research aims to bring better care to patients with head and neck cancer.

Gum Cells May Trigger Inflammation, Gum Disease

image of IL23 and controlAside from their role as a protective physical barrier, epithelial cells that line the mouth and gums may directly activate the immune system, triggering chronic inflammation that leads to gum disease. A study led by NIDCR Associate Scientific Director Niki Moutsopoulos, D.D.S., Ph.D., provides evidence that these cells may play a bigger role in disease development than previously thought.

Gum Disease-Related Bacteria Tied to Colorectal Cancer

colorized image of CRC_FNScientists identified a specific subtype of Fusobacterium nucleatum — a type of bacteria implicated in gum disease — that may promote the growth of colorectal tumors. The study, which was partly funded by NIDCR, suggests that therapies targeting these bacteria in tumors could help reduce the severity of some colorectal cancers.

Topical Solution Halts Tooth Decay in Children

photo of a dentist with patientA topical liquid, silver diamine fluoride (SDF), can stop tooth decay in young children, according to a clinical trial funded by NIDCR. SDF can be easily and painlessly swabbed onto cavities and could be a potential tool for improving children’s oral health.

Bone Marrow Cells Reveal Secret Weapon to Battle Bacteria

stem cellsNIH’s I am Intramural Blog recently featured the work of NIDCR Senior Investigator Eva Mezey, M.D., Ph.D., and her colleagues, who discovered that bone marrow stem cells make hepcidin, a small molecule that can kill bacteria and tame overreactive immune responses caused by inflammation.

Wrecking Cellular Recycling to Learn About Lung Cancer

photo of a young woman sitting at  a table speakingIn a SciBites video from the NIH Intramural Research Program, Maya English, a postbaccalaureate research fellow in the lab of NIDCR’s Achim Warner, Ph.D., described her research on how protein recycling goes awry in certain lung cancers. What she learns may inform treatments for diseases that arise from faulty recycling.

The Perplexing Pancreas

image of pancreatitis cellsThe NIH Catalyst recently highlighted investigators, including NIDCR’s Shmuel Muallem, Ph.D., who are using multifaceted approaches to better understand pancreatic disease. Dr. Muallem’s lab is exploring how drugs approved for cystic fibrosis might be repurposed to correct dysfunctional fluid secretion in mouse models of pancreatitis and Sjögren’s disease.

UM Research Discovers New Way to Generate Human Cartilage 

University of Montana – April 10, 2024

Scientists Identify Key Step in How Teeth Develop in the Womb

Cedars-Sinai Medical Center – April 3, 2024

New Resource for NIH-Affiliated Researchers: NIH Cloud Lab

graphic depicting a spoke and wheelNIH-affiliated researchers and students can receive up to 90 days of free access to NIH Cloud Lab, a self-paced, interactive, cloud-based training program and commercial cloud service. Researchers and students can explore cloud capabilities for research and access bioinformatic tutorials and data sets in a secure, NIH-approved environment.

NIH Guidance on Marking Changes in Resubmission Application

Graphic depicting a hand reaching out of a computer and a man signing a documentStarting May 25, 2024, markups should not be used to identify changes in grant resubmission applications. Applicants should include in the Introduction attachment a summary of all substantial changes and a response to weaknesses raised by the prior review.

NIH Scientists Find Weak Points on Epstein-Barr Virus

Epstein-Barr virus proteinBy studying the interactions between lab-generated monoclonal antibodies and an Epstein-Barr virus (EBV) protein, researchers at the National Institute of Allergy and Infectious Diseases have uncovered new details that could aid treatment and vaccine development. EBV can reside in cell linings of the throat, sometimes leading to nose and throat cancer.

NIH Launches Research Network To Evaluate Cancer Screening Technologies

photo of a person in a lab coat drawing blood from a patient's armThe newly launched Cancer Screening Research Network will evaluate the benefits and harms of promising new technologies for cancer screening and determine how to incorporate them into the standard of care. This clinical trials network will support the Biden-Harris administration’s Cancer Moonshot program.

Researchers Optimize Genetic Tests To Tackle Health Disparities

graphic of part of the globe with icons of people at places all over the globeA recent NIH-funded study has devised new ways to improve a genetic testing method called a polygenic risk score to more accurately assess disease risk regardless of genetic ancestry. Genomic datasets used to calculate scores often overrepresent people of European ancestry, which can contribute to health disparities.

275 Million New Genetic Variants Identified

image of scientist working at a computerResearchers have discovered more than 275 million previously unreported genetic variants, which were identified from data shared by nearly 250,000 participants of NIH’s All of Us Research Program. These results can help scientists better understand genetic influences on health and disease, especially in communities that have been left out of research in the past. 

USDOL Issues Comprehensive Employer Guidance on Long COVID

The United States Department of Labor (USDOL) has issued a comprehensive set of resources that can be accessed below for employers on dealing with Long COVID.

Supporting Employees with Long COVID: A Guide for Employers

The “Supporting Employees with Long COVID” guide from the USDOL-funded Employer Assistance and Resource Network on Disability Inclusion (EARN) and Job Accommodation Network (JAN) addresses the basics of Long COVID, including its intersection with mental health, and common workplace supports for different symptoms.  It also explores employers’ responsibilities to provide reasonable accommodations and answers frequently asked questions about Long COVID and employment, including inquiries related to telework and leave.

Download the guide

Accommodation and Compliance: Long COVID

The Long COVID Accommodation and Compliance webpage from the USDOL-funded Job Accommodation Network (JAN) helps employers and employees understand strategies for supporting workers with Long COVID.  Topics include Long COVID in the context of disability under the Americans with Disabilities Act (ADA), specific accommodation ideas based on limitations or work-related functions, common situations and solutions, and questions to consider when identifying effective accommodations for employees with Long COVID.  Find this and other Long COVID resources from JAN, below:

Long COVID, Disability and Underserved Communities: Recommendations for Employers

The research-to-practice brief “Long COVID, Disability and Underserved Communities” synthesizes an extensive review of documents, literature and data sources, conducted by the USDOL-funded Employer Assistance and Resource Network on Disability Inclusion (EARN) on the impact of Long COVID on employment, with a focus on demographic differences.  It also outlines recommended actions organizations can take to create a supportive and inclusive workplace culture for people with Long COVID, especially those with disabilities who belong to other historically underserved groups.

Read the brief

Long COVID and Disability Accommodations in the Workplace

The policy brief “Long COVID and Disability Accommodations in the Workplace” explores Long COVID’s impact on the workforce and provides examples of policy actions different states are taking to help affected people remain at work or return when ready.  It was developed by the National Conference of State Legislatures (NCSL) as part of its involvement in USDOL’s State Exchange on Employment and Disability (SEED) initiative.

Download the policy brief

Understanding and Addressing the Workplace Challenges Related to Long COVID

The report “Understanding and Addressing the Workplace Challenges Related to Long COVID” summarizes key themes and takeaways from an ePolicyWorks national online dialogue through which members of the public were invited to share their experiences and insights regarding workplace challenges posed by Long COVID.  The dialogue took place during summer 2022 and was hosted by USDOL and its agencies in collaboration with the Centers for Disease Control and Prevention and the U.S. Surgeon General.

Download the report

Working with Long COVID

The USDOL-published “Working with Long COVID” fact sheet shares strategies for supporting workers with Long COVID, including accommodations for common symptoms and resources for further guidance and assistance with specific situations.

Download the fact sheet

COVID-19: Long-Term Symptoms

This USDOL motion graphic informs workers with Long COVID that they may be entitled to temporary or long-term supports to help them stay on the job or return to work when ready, and shares where they can find related assistance.

Watch the motion graphic

A Personal Story of Long COVID and Disability Disclosure

In the podcast “A Personal Story of Long COVID and Disability Disclosure,” Pam Bingham, senior program manager for Intuit’s Diversity, Equity and Inclusion in Tech team, shares her personal experience of navigating Long COVID symptoms at work.  The segment was produced by the USDOL-funded Partnership on Employment and Accessible Technology (PEAT) as part of its ongoing “Future of Work” podcast series.

Listen to the podcast

HHS OIG Issues Annual Report on State MFCUs

Per the notice below, the Office of the Inspector General (OIG) of the United States Department of Health and Human Services (HHS) has issued its annual report on the performance of state Medicaid Fraud Control Units (MFCUs).

Medicaid Fraud Control Units Fiscal Year 2023 Annual Report (OEI-09-24-00200) 

Medicaid Fraud Control Units (MFCUs) investigate and prosecute Medicaid provider fraud and patient abuse or neglect. OIG is the Federal agency that oversees and annually approves federal funding for MFCUs through a recertification process. This new report analyzed the statistical data on annual case outcomes—such as convictions, civil settlements and judgments, and recoveries—that the 53 MFCUs submitted for Fiscal Year 2023.  New York data is as follows:

Outcomes

  • Investigations1 - 556
  • Indicted/Charged - 9
  • Convictions - 8
  • Civil Settlements/Judgments - 28
  • Recoveries2 - $73,204,518

Resources

  • MFCU Expenditures3 - $55,964,293
  • Staff on Board4 - 257

1Investigations are defined as the total number of open investigations at the end of the fiscal year.

2Recoveries are defined as the amount of money that defendants are required to pay as a result of a settlement, judgment, or prefiling settlement in criminal and civil cases and may not reflect actual collections.  Recoveries may involve cases that include participation by other Federal and State agencies.

3MFCU and Medicaid Expenditures include both State and Federal expenditures.

4Staff on Board is defined as the total number of staff employed by the Unit at the end of the fiscal year.

Read the Full Report

View the Statistical Chart

Engage with the Interactive Map

GAO Issues Report on Medicaid Managed Care Service Denials and Appeal Outcomes

The United States Government Accountability Office (GAO) has issued a report on federal use of state data on Medicaid managed care service denials and appeal outcomes.  GAO found that federal oversight is limited because it doesn't require states to report on Medicaid managed care service denials or appeal outcomes and there has not been much progress on plans to analyze and make the data publicly available.  To read the GAO report on federal use of state data on Medicaid managed care service denials and appeal outcomes, use the first link below.  To read GAO highlights of the report on federal use of state data on Medicaid managed care service denials and appeal outcomes, use the second link below.
https://www.gao.gov/assets/d24106627.pdf  (GAO report on federal use of state data on Medicaid managed care service denials and appeal outcomes)
https://www.gao.gov/assets/d24106627_high.pdf  (GAO highlights on federal use of state data on Medicaid managed care service denials and appeal outcomes)

CMS Issues Latest Medicare Regulatory Activities Update

The Centers for Medicare and Medicaid Services (CMS) has issued its latest update on its regulatory activities in the Medicare program.  While dentistry is only minimally connected to the Medicare program, Medicare drives the majority of health care policies and insurance reimbursement policies throughout the country.  Therefore, it always pays to keep a close eye on what CMS is doing in Medicare.  To read the latest CMS update on its regulatory activities in Medicare, use the link below.
https://www.cms.gov/training-education/medicare-learning-network/newsletter/2024-03-14-mlnc